Skip to main content

CleopatraRX

Menu
BOOK CONSULTATION

Brain-First Menopause Care

Your Brain
Deserves Better.

It’s not stress. It’s not aging.
It’s your brain on menopause — and it’s treatable.

Developed by Dr. Rhonda Voskuhl, a UCLA neurologist and NIH-funded researcher, PearlPAK® is the first menopause treatment designed to target cognitive health — not just hot flashes.

TAKE THE ASSESSMENT

40 yrs

SAFETY DATA

$54M

NIH FUNDED RESEARCH

$147/mo

Per Month, All-In

24/7

CONCIERGE SUPPORT

40 yrs

EUROPEAN
SAFETY DATA

$54M

NIH FUNDED RESEARCH

$147/mo

RX + DELIVERY INCLUDED

24/7

CONCIERGE SUPPORT

AS SEEN IN

Image gallery marquee
Image gallery marquee
Image gallery marquee
Image gallery marquee

You’re Not Imagining It

 

This Is What
Menopause Does
to the Brain.

70% of women in menopause experience brain fog. Yet most receive no treatment for their cognitive symptoms. CleopatraRX is changing that — with science that takes women’s brains seriously.

  • Brain Fog
  • Memory Loss
  • Word Finding
  • Poor Concentration
  • Mood Swings
  • Sleep Disruption
  • Hot Flashes
  • Fatigue
SEE THE SCIENCE

Estriol vs. Standard MHT — Key Differences

Why Estriol

Changes Everything

Most hormone therapies use estradiol.
PearlPAK® uses systemic estriol.

CleopatraRx
PearlPAK® — Oral Estriol (E3)
Brain-first Menopause Care
Standard HRT
Standard MHT — Estradiol (E2)
Conventional hormone therapy.
Primary Receptor
ERβ — brain & nervous system
~ Broad — ERα + ERβ
Breast Tissue Exposure
Weak — ERβ selective
↑ Strong — ERα mediated
Converts to Estrone
No
↑ Yes — higher clotting risk with oral; lower with transdermal
Brain Fog Relief
Primary indication
~ Unclear secondary / variable
Vasomotor Relief (Hot Flashes, Night Sweats)
Very Good
Excellent
US Availability
Compounded — licensed pharmacy
~ FDA-approved (patches in shortage 2026)
Safety Data
40+ years (Asia & Europe)
Decades of use
TAKE THE ASSESSMENT

Built for Women. By a Woman.

"Women's cognitive struggles during menopause were too often dismissed or misunderstood. I dedicated my career to changing that narrative — and giving women's health the scientific rigor it deserves."

Rhonda Voskuhl, MD

Neurologist · UCLA Distinguished Professor · Pioneering Women’s Brain Health

  • UCLA NEUROLOGY
  • NIH PRINCIPAL INVESTIGATOR
  • FEATURED ON OPRAH
  • 40+ YEARS RESEARCH
MEET DR. VOSKUHL

FEATURED COVERAGE

“The Menopause Revolution” — An Oprah Special
WATCH THE CLIP

Patient Outcomes

What Happens When You
Finally Get the Right Treatment

"

★★★★★

Performance · Cognitive

“My concentration significantly improved. I’m tackling business challenges more easily. My brain feels sharp and quick again — like it did a decade ago.”

Diane M. — Executive, Age 54

"

★★★★★

Personality · Mood · Wit

“I noticed my wife’s quick wit had diminished. Sometime after she started PearlPAK, her wit gradually returned. She makes me laugh again.”

Robert S. — Husband of Patient

"

★★★★★

Memory · Preventitive

“After learning I carry the APEO4 gene and seeing Alzheimer’s in my family, I knew I had to do something to protect my brain. PearlPAK helped bring my clarity back and made me feel like myselfe agian.”

Heather H. — Health Coach, Age 58

"

★★★★★

Sleep · Safety

“After years of conflicting hormone advice and concerns about long-term safety, PearlPAK finally felt like the right fit for me. I’m sleeping better, my skin and eyes feel less dry, and I feel more mentally clear.”

Lisa S. — Financial Planner, Age 68

"

★★★★★

Performance · Cognitive

“My concentration significantly improved. I’m tackling business challenges more easily. My brain feels sharp and quick again — like it did a decade ago.”

Diane M. — Executive, Age 54

"

★★★★★

Personality · Mood · Wit

“I noticed my wife’s quick wit had diminished.
Sometime after she started PearlPAK®, her wit
gradually returned. She makes me laugh again.”

Robert S. — Husband of Patient

"

★★★★★

Identity · Mood

“Without estrogen, it felt like I was trying to live my life from the bottom of a well. Everything was dark and it took so much effort just to think. After starting PearlPAK, it felt like I came back up into the sunshine again. My brain feels like mine again..”

Stephanie S. — Business Owner, Age 56

"

★★★★★

Memory · Preventative

“After learning I carry the APOE4 gene and seeing Alzheimer’s in my family, I knew I had to do something to protect my brain. PearlPAK helped bring my clarity back and made me feel like myself again.”

Heather H. — Health Coach, Age 58

"

★★★★★

Identity · Performance

“My brain is core to who I am, and when the fog started affecting my work, I knew something wasn’t right. PearlPAK helped me feel clear, focused, and like myself again.”

Lauren A. — Retired Educator, Age 66

"

★★★★★

Brain Fog · Mood · Identity

“I originally came in for sleep issues and brain fog, but within a few months I noticed I was thinking more clearly and feeling more like myself again. It’s made a meaningful difference in how I show up every day with my family.”

Linda M. — Retired Postal Worker, Age 63

"

★★★★★

Sleep · Cognitive

“After years of conflicting hormone advice and concerns about long-term safety, PearlPAK finally felt like the right fit for me. I’m sleeping better, my skin and eyes feel less dry, and I feel more mentally clear.”

Lisa S. — Financial Planner, Age 68

"

★★★★★

Memory · Prevention

“Watching my mother’s memory decline made every moment of brain fog feel terrifying. PearlPAK gave me back the mental clarity and confidence I need to perform at work and feel hopeful about my future.”

Megan R. — Corporate Attorney

Who PearlPAK® Is For

Precision Care for Every Stage

PERFORMANCE-DRIVEN

01

The High-Achieving Professional

You’ve built a career on your sharp mind. Brain fog isn’t just uncomfortable — it threatens everything you’ve worked for. PearlPAK® was designed for women who can’t afford to lose their edge.

FORWARD-THINKING

02

The Proactive Wellness Optimizer

You treat your body as a long-term investment. You want science-backed, bioidentical, precision medicine — not guesswork or one-size-fits-all supplements.

DETAIL-ORIENTED

03

The Cautious Researcher

You’ve heard conflicting things about HRT. You need a provider who shows their evidence. Our 40-year safety record and NIH-funded data give you confidence, not just promises.

ACTION-FORWARD

04

The Perimenopause Planner

You’re in your early 40s noticing subtle shifts. You want to act before symptoms peak — protecting cognitive function while the window for intervention is widest.

Getting Back to Clarity

Three Steps to Your
Personalized PearlPAK®

Simple, concierge-level care — delivered to your door. $147/month. Prescription, pharmacy, delivery, and care team included.

01
Take the First Step
Complete our 2-minute Brain Fog Assessment or book a quick nurse consult. We review your symptoms, health history, and goals.
02
Talk with a Nurse
A menopause-trained practitioner reviews your full picture and confirms PearlPAK® is the right fit. Real clinical care, not an algorithm.
03
Receive Your PearlPAK®
Your prescription is sent to a licensed pharmacy and shipped to your door. Plus 12 months of concierge follow-up as your needs evolve.
BOOK YOUR CONSULTATION

12 MONTHS  OF TAILORED CARE

 

Your Treatment Journey
Phase by Phase​

Most women see relief at 3 months and meaningful
cognitive improvement 12 months of consistent treatment.

Phase 1
Day 1
Consultation & Activation
A clinician reviews your health history, symptoms, and confirms PearlPAK® is right for you. Your prescription is activated and shipped.
Phase 2
Month 3
Vasomotor Relief
Hot flashes and night sweats begin to diminish. Sleep quality improves. Your body starts finding its new equilibrium.
Phase 3
Months 4-6
Physical Comfort
Vaginal dryness and urinary urgency improve. Energy levels stabilize. You feel more like yourself in your body again.
Phase 4
Month 12
Cognitive Restoration
Brain fog lifts. Memory sharpens. Concentration returns. This is the milestone other treatments don't even aim for.

CLARITY IS POSSIBLE

 

A Doctor Who Gets You.
A Treatment That Works.

You’re not imagining it. Brain fog, forgetfulness, and mental fatigue during menopause are real — and you deserve a solution made just for you.

BOOK YOUR CONSULTATION
  • NIH-Funded Research
  • 40-Year Safety Record
  • Prescription Included
  • 24/7 Concierge Care

Black Friday Sale Alert

New members enjoy 40% off your PearlPAK subscription for the first 3 months!

40% OFF

$89/month for 3 months

Use Code: BLACKFRIDAY89

Start Your Treatment