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CleopatraRX

Brain-First Menopause Care

Your Brain
Deserves Better.

It’s not stress. It’s not aging.
It’s your brain on menopause — and it’s treatable.

Developed by Dr. Rhonda Voskuhl, a UCLA neurologist and NIH-funded researcher, PearlPAK® is the first menopause treatment designed to target cognitive health — not just hot flashes. 

40 yrs

SAFETY DATA

$54M

NIH FUNDED RESEARCH

$147/mo

Per Month, All-In

24/7

CONCIERGE SUPPORT

40 yrs

EUROPEAN
SAFETY DATA

$54M

NIH FUNDED RESEARCH

$147/mo

RX + DELIVERY INCLUDED

24/7

CONCIERGE SUPPORT

NEW PUBLISHED RESEARCH · UCLA CASE SERIES

PearlPAK® improved cognition in every participant

In a new UCLA study led by Dr. Voskuhl, twenty menopausal women took PearlPAK, a personalized estriol and progesterone regimen, for twelve months. In the preliminary, uncontrolled case series, every participant reported improvement across the six cognitive domains menopause affects most: brain fog, concentration, working memory, processing speed, verbal memory, and problem solving.

AS SEEN IN

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You’re Not Imagining It

 

This Is What
Menopause Does
to the Brain.

70% of women in menopause experience brain fog. Yet most receive no treatment for their cognitive symptoms. CleopatraRX is changing that — with science that takes women’s brains seriously.

Estriol vs. Standard MHT — Key Differences

Why Estriol

Changes Everything

Most hormone therapies use estradiol.
PearlPAK® uses systemic estriol.

CleopatraRx
PearlPAK® — Oral Estriol (E3)
Brain-first Menopause Care
Standard HRT
Standard MHT — Estradiol (E2)
Conventional hormone therapy.
Primary Receptor
ERβ — brain & nervous system
~ Broad — ERα + ERβ
Breast Tissue Exposure
Weak — ERβ selective
Strong — ERα mediated
Converts to Estrone
No
Yes — higher clotting risk with oral; lower with transdermal
Brain Fog Relief
Primary indication
~ Unclear secondary / variable
Vasomotor Relief (Hot Flashes, Night Sweats)
Very Good
Excellent
US Availability
Compounded — licensed pharmacy
~ FDA-approved (patches in shortage 2026)
Safety Data
40+ years (Asia & Europe)
Decades of use

Built for Women. By a Woman.

"Women's cognitive struggles during menopause were too often dismissed or misunderstood. I dedicated my career to changing that narrative — and giving women's health the scientific rigor it deserves."

Rhonda Voskuhl, MD

Neurologist · UCLA Distinguished Professor · Pioneering Women’s Brain Health

FEATURED COVERAGE

“The Menopause Revolution” — An Oprah Special

Patient Outcomes

What Happens When You
Finally Get the Right Treatment

Who PearlPAK® Is For

Precision Care for Every Stage

Getting Back to Clarity

Three Steps to Your
Personalized PearlPAK®

Simple, concierge-level care — delivered to your door. $147/month. Prescription, pharmacy, delivery, and care team included.

01
Take the First Step
Complete our 2-minute Brain Fog Assessment or book a quick nurse consult. We review your symptoms, health history, and goals.
02
Talk with a Nurse
A menopause-trained practitioner reviews your full picture and confirms PearlPAK® is the right fit. Real clinical care, not an algorithm.
03
Receive Your PearlPAK®
Your prescription is sent to a licensed pharmacy and shipped to your door. Plus 12 months of concierge follow-up as your needs evolve.

12 MONTHS  OF TAILORED CARE

 

Your Treatment Journey
Phase by Phase​

Most women see relief at 3 months and meaningful
cognitive improvement 12 months of consistent treatment.

Phase 1
Day 1
Consultation & Activation
A clinician reviews your health history, symptoms, and confirms PearlPAK® is right for you. Your prescription is activated and shipped.
Phase 2
Month 3
Vasomotor Relief
Hot flashes and night sweats begin to diminish. Sleep quality improves. Your body starts finding its new equilibrium.
Phase 3
Months 4-6
Physical Comfort
Vaginal dryness and urinary urgency improve. Energy levels stabilize. You feel more like yourself in your body again.
Phase 4
Month 12
Cognitive Restoration
Brain fog lifts. Memory sharpens. Concentration returns. This is the milestone other treatments don't even aim for.

6 cognitive domains · 12 months · 100% reported improvement

The research behind PearlPAK®

A new UCLA study measured cognition before treatment and again at twelve months. Every participant reported meaningful improvement across all six domains at 12 months — a result that held across all ages and whether or not the women had tried hormone therapy before.

CLARITY IS POSSIBLE

 

A Doctor Who Gets You.
A Treatment That Works.

You’re not imagining it. Brain fog, forgetfulness, and mental fatigue during menopause are real — and you deserve a solution made just for you.